Calculate the correct Galliprant (Grapiprant) dose for your dog's osteoarthritis pain.
Enter your dog's weight to calculate the recommended dose.
Calculated Dose
⚠️ Galliprant is only approved for dogs ≥ 3.6 kg (8 lbs).
Give on an empty stomach once daily.
Enter your dog's weight above
⚕️ Galliprant is a prescription-only NSAID. This calculator provides a dose reference only. Always consult your veterinarian for a diagnosis and appropriate treatment plan for your dog's joint condition.
Galliprant (Grapiprant) is a prescription NSAID used to control pain and inflammation associated with canine osteoarthritis. Unlike traditional NSAIDs, it selectively targets the EP4 prostaglandin receptor, making it suitable for dogs that cannot tolerate conventional NSAIDs.
The recommended dose of Galliprant is 2 mg/kg once daily, administered on an empty stomach (at least 1 hour before or 2 hours after feeding) for best absorption. It is approved for dogs ≥ 9 months of age weighing ≥ 3.6 kg (8 lbs).
Galliprant tablets are available in 20 mg, 60 mg, and 100 mg strengths. Tablets are scored and can be split. Select the tablet size that most closely matches the calculated dose.
Galliprant is generally well tolerated but may cause vomiting, diarrhoea, and soft stools in some dogs. It should not be used concurrently with other NSAIDs or corticosteroids. Baseline bloodwork and periodic monitoring is recommended for long-term use.
Calculate grapiprant (Galliprant) dosing by weight — EP4 receptor antagonist for osteoarthritis pain.
Minimum weight: 3.6 kg (8 lbs). Not for puppies under 9 months.
Galliprant is not approved for dogs under 9 months of age.
Galliprant is best absorbed on an empty stomach. Give 1 hour before food.
Galliprant is an EP4 prostaglandin receptor antagonist — the first in the piprant class of NSAIDs. Unlike traditional NSAIDs (e.g. carprofen, meloxicam), grapiprant blocks the EP4 receptor rather than inhibiting COX-1/COX-2 enzymes, targeting the pain and inflammation pathway more selectively.
Piprant-Class NSAID — EP4 Prostaglandin Receptor Antagonist
Grapiprant is the first in the piprant class of non-steroidal anti-inflammatory drugs. Rather than inhibiting COX enzymes (as traditional NSAIDs do), grapiprant selectively blocks the EP4 receptor — the primary receptor through which prostaglandin E₂ mediates pain and inflammation in osteoarthritis. This targeted approach aims to provide analgesia with a potentially different GI and renal safety profile.
Osteoarthritis-associated pain and inflammation in dogs ≥ 9 months and ≥ 3.6 kg. Only licensed NSAID of the piprant class for veterinary use.
| Indication | Dose | Frequency |
|---|---|---|
| OA pain management | 2 mg/kg | q24h PO on empty stomach |
| Minimum weight | ≥ 3.6 kg | Do not dose below this |
| Minimum age | ≥ 9 months | Not approved for puppies |
Liver enzymes (ALT), renal function (BUN, creatinine), urinalysis at baseline and every 6–12 months. Owner-reported GI signs and appetite changes at each recheck.
Traditional NSAIDs (carprofen, meloxicam, deracoxib) work by inhibiting COX-1 and/or COX-2 enzymes, reducing prostaglandin production broadly. Galliprant (grapiprant) takes a different approach — it specifically blocks the EP4 receptor, the primary receptor responsible for prostaglandin E2-mediated pain and inflammation in osteoarthritis. Because it targets the pathway downstream and more selectively, it may have a different GI and renal safety profile, though all NSAIDs carry risk and require monitoring. Galliprant should not be combined with other NSAIDs or steroids.
Studies show that a high-fat meal reduces grapiprant’s peak plasma concentration (Cmax) by approximately 35% and delays absorption. For consistent, reliable pain control — especially important during the first few weeks of therapy — dosing on an empty stomach ensures predictable drug levels. Ideally, give the tablet at least 1 hour before the first meal of the day. If your dog consistently refuses tablets without food, speak to your vet — some clinicians allow a small, low-fat treat as a pill pocket.
Galliprant is FDA-approved only for dogs ≥ 9 months of age and weighing ≥ 3.6 kg (8 lbs). Use below these thresholds has not been studied and is not licensed. Puppies under 9 months are still developing joint cartilage and their renal function may not be fully mature — the safety profile in this age group is unknown. For very small dogs close to the 3.6 kg minimum, always double-check the calculated dose with your vet before dispensing.
While Galliprant’s label does not mandate pre-treatment bloodwork, most veterinary internists recommend baseline bloodwork (chemistry panel + urinalysis) before starting and every 6–12 months during chronic use. Key parameters are BUN, creatinine, ALT, and urine specific gravity. Watch for clinical signs of GI upset (vomiting, diarrhoea, decreased appetite), changes in water intake/urination, or jaundice. Stop the drug and contact your vet immediately if any adverse signs develop.
Galliprant must NOT be combined with other NSAIDs (carprofen, meloxicam, aspirin, deracoxib) or corticosteroids (prednisone, dexamethasone) due to risk of additive GI and renal toxicity. A washout period of at least 24 hours (or 5–7 days for some NSAIDs) is required when switching between products. It can often be safely paired with adjunct analgesics such as gabapentin, amantadine, or omega-3 fatty acids under veterinary guidance. Always confirm combinations with your vet.
Galliprant comes in 20 mg, 60 mg, and 100 mg tablets, all of which are scored for splitting. The auto-select function in the calculator above chooses the tablet size that minimises pill burden and wastage for your dog’s weight. For small dogs near 3.6 kg, the 20 mg tablet (dosed as a half or whole) is most practical. For large breeds, the 100 mg tablet reduces the number of tablets needed per dose. Always use a proper pill splitter for accurate halving.
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