Sildenafil for Dogs: Safe Canine Heart Medication

Vets often give dogs and cats Sildenafil for pulmonary hypertension¹. This medicine, known as Viagra, Revatio, or Vizarsin, helps improve their energy and life quality¹.

As a pet owner, knowing about Sildenafil is key. We’ll cover how to use it safely to keep your dog healthy and happy. This guide will give you the info you need to care for your pet well.

Key Takeaways

• Sildenafil is a common veterinary medication used to treat pulmonary hypertension in dogs and cats.
• The drug has been shown to improve energy, exercise tolerance, and overall quality of life in animals with this condition.
• Sildenafil requires a prescription from a veterinarian and is sold per tablet.
• The usual dosage range for dogs is 2.2-6.6 mg/lb taken 2-3 times daily.
• Reported side effects in dogs include gastrointestinal upset and skin redness or flushing.

What is Sildenafil for Dogs?

Understanding the Drug’s Nature and Purpose

Sildenafil is a medicine that helps dogs and cats with heart and lung problems. These problems cause high blood pressure in the lungs, known as pulmonary hypertension². This drug makes the muscles around small blood vessels in the lungs relax. This helps decrease the heart’s workload².

Pulmonary hypertension means the blood pressure in the lungs’ arteries is too high. This makes the heart work too hard². Sildenafil can lower this pressure, improve life quality, and increase survival time for dogs with this condition². Dogs need 1 to 3 mg of sildenafil every 8 to 12 hours to treat this².

Sildenafil also helps dogs with megaesophagus by reducing food regurgitation³. A study showed nine out of ten dogs ate better with sildenafil³. It helps open the lower esophageal sphincter, making eating easier³.

This drug is also good for puppies with congenital idiopathic megaesophagus⁴. A study of 21 puppies found it helped them eat better and gain more weight⁴. Lab tests showed it can relax the muscles in the esophagus⁴.

Sildenafil is a key medicine for dogs with breathing and digestive issues². It’s versatile and effective, making it a top choice for pet owners and vets²³⁴.

Sildenafil for dog: Drug Information and Indications

Sildenafil is a key medication for dogs, helping with many health issues. It’s mainly used for treating pulmonary hypertension in dogs, especially in small and older breeds². It also helps with megaesophagus and myxomatous mitral valve disease.

Studies show that sildenafil greatly improves life quality for dogs with pulmonary hypertension. It lowers blood pressure in the lungs, helps dogs exercise better, and can even make them live longer²⁵. Dogs usually get 1 to 3 mg of sildenafil every 8 to 12 hours².

Sildenafil isn’t FDA-approved for dogs but is made by special pharmacies². Despite this, it has shown great results in many studies. Vets widely use it for treating dogs with pulmonary hypertension, megaesophagus, and heart issues.

Working with a vet is key when using sildenafil for dogs. It’s important to adjust the dosage and keep a close eye on the dog’s health⁵.

Sildenafil also has benefits for wound healing⁶. It helps wounds heal faster and improves skin flap survival in animals and humans⁶. The exact reasons for these effects are still being studied, but sildenafil’s potential in veterinary medicine is exciting.

Administering Sildenafil for Dogs

Dosage, Frequency, and Directions

Your vet will tell you exactly how to give sildenafil to your dog⁷. For dogs with high blood pressure in the lungs, the usual dose is 0.5 mg to 3 mg per kg every 8 to 24 hours⁷. For megaesophagus, give 1 mg per kg every 12 hours⁷. If you forget to give a dose, just give the next one when you remember, but don’t give two doses at once⁸. Sildenafil is usually given every 8-12 hours, based on the condition it’s for⁸.

Give sildenafil without food⁸. But, if your dog vomits or has stomach upset after taking it on an empty stomach, call your vet. They might suggest giving it with a little food⁸. If vomiting keeps happening, tell your vet right away⁸.

Sildenafil is a short-acting medication that stops working within 24 hours for most dogs.⁷ To make sure your pet gets the most out of the treatment, follow the dosage and frequency your vet says to⁸.

Remember⁸, sildenafil is often used in dogs for high blood pressure in the lungs⁸. In vet medicine, many drugs, like sildenafil, are used for certain conditions in animals⁸. By giving this medicine as your vet says, you can help your dog with their heart condition and make them feel better⁸⁹⁷.

Potential Side Effects and Precautions

Sildenafil for dogs is usually safe, but watch out for some side effects. These can include vomiting, diarrhea, less interest in food, and skin looking flushed, especially near the belly or groin¹⁰. Don’t use it on animals with low blood pressure, shock, blood loss, or heart or lung issues that won’t get better with this drug¹⁰.

Sildenafil is also in the drug Viagra, used for human erectile dysfunction¹¹. Viagra helps improve blood flow to the male genital area¹¹. But it doesn’t work on the brain and needs natural arousal for an erection¹¹. While it’s a known treatment for men, it’s not meant for dogs because the effects and warnings are different.

Using this drug is only allowed by or under a vet’s order¹⁰. Always follow your vet’s advice and watch your dog for any bad reactions. If you see something that worries you, call your vet right away.

Always be careful when giving your dog any medicine. Knowing the possible side effects and warnings of sildenafil helps keep your dog safe and healthy¹⁰.

In summary, sildenafil can be helpful for some dog health issues, but always talk to your vet and watch for any bad reactions. Being informed and active helps keep your pet safe and well¹⁰.

Drug Interactions and Monitoring

Medications and Follow-up Care

When giving sildenafil to dogs, it’s key to check with your vet about other meds your pet takes¹². Don’t mix sildenafil with drugs that lower blood pressure, like nitrates or alpha-blockers¹³. Also, some meds like cimetidine or erythromycin might not work well with sildenafil.

Your vet might suggest special checks or tests if your pet is on sildenafil¹². This is to make sure the medicine is working right and to adjust the treatment if needed.

It’s vital to keep a close eye on your pet when they’re on sildenafil¹². Your vet might suggest tests or checks based on your dog’s needs and other meds they’re on.

Tell your vet about all the meds and supplements your dog uses¹³. This helps your vet make the best choices for using sildenafil and watching how your pet reacts to it¹²¹⁴¹³.

Storage and Overdose Concerns

When giving sildenafil to dogs, it’s important to store it right and know about overdose risks. The way you store this medicine depends on the strength or type given¹⁵. Always check the label or ask a vet or pharmacist for the right way to store it.

Usually, you should keep sildenafil at room temperature between 67-77°F (19-25°C)¹⁵. It’s okay if the temperature is between 59-86°F (15-30°C) for a short time. But, keep the container closed to keep moisture and light out¹⁵. For special sildenafil mixes, follow the pharmacy’s storage advice.

Sildenafil is approved for people under the names Viagra® and Revatio®, but not for pets¹⁵. Yet, some pets might get special mixes if they need something not covered by approved drugs¹⁶.

If a pet accidentally takes too much sildenafil, call a vet or the ASPCA’s Animal Poison Control Center right away¹⁵. Signs of too much include very low blood pressure, weakness, vomiting, fast heart rate, collapse, or feeling very tired¹⁵. If a person takes too much, call the National Capital Poison Center at 800.222.1222¹⁶.

In summary, storing sildenafil right and knowing about overdose risks is key when giving it to dogs. Talking to a vet or pharmacist for advice on storage and what to do in an emergency helps use this medicine safely and responsibly.

Sildenafil for Dogs: Comparing with Similar Drugs

Sildenafil is a top choice for treating pulmonary hypertension in dogs. Yet, it’s not the only option. Vets might also look at bosentan and tadalafil for these dogs¹⁷.

Sildenafil helps by making blood vessels in the lungs relax and widen. This makes it easier for the heart to pump blood through them¹⁷. Bosentan and tadalafil work differently but have similar effects on the lungs. The right drug depends on the dog’s health and the vet’s experience with each medicine.

Sildenafil is the most studied for treating pulmonary hypertension in dogs¹⁷. But, tadalafil and bosentan could work too in some cases¹⁸. The choice depends on the dog and the vet’s advice.

Choosing the right medication should be done with a vet’s help. They can pick the safest and most effective treatment for the dog’s condition¹⁷¹⁹¹⁸.

Benefits and Improvements in Quality of Life

Sildenafil is a key drug for dogs with lung problems²⁰. It helps them feel more energetic and able to exercise. This makes them happier overall.

Studies show that adding ambrisentan to sildenafil helps dogs eat better and move more²⁰. Using both ambrisentan and tadalafil together also lowers the chance of serious health issues in people and dogs²⁰.

Sildenafil also helps dogs with megaesophagus eat better²¹. It makes it easier for food to go down. Owners saw less regurgitation and their dogs gained weight²¹.

Sildenafil helps dogs with lung issues breathe easier and move better²². It’s shown to be very helpful for dogs with megaesophagus and heart valve problems²². This shows how important sildenafil is for dogs’ health and happiness.

Enhancing Energy, Exercise Tolerance, and Wellbeing

Sildenafil makes blood vessels in the lungs relax. This helps the heart work less hard and improves blood flow²⁰. It’s a big help for dogs with lung issues, making them more energetic and happy.

“Sildenafil has been a game-changer for our dog with pulmonary hypertension. We’ve seen a remarkable improvement in her energy, stamina, and overall happiness since starting the medication.”

Research keeps showing how useful sildenafil is for dogs²¹. It makes dogs with different health problems feel better. This makes it a key tool for improving dogs’ lives²⁰²¹²².

Understanding the Drug’s Mode of Action

Sildenafil is a common drug for dogs that works in a special way. It stops an enzyme called phosphodiesterase type 5 (PDE5) from breaking down a molecule called cyclic guanosine monophosphate (cGMP)²³. This lets cGMP build up, causing muscles to relax and blood vessels to widen in the lungs²³.

This makes it easier for the heart to work and helps with a condition called pulmonary hypertension in dogs²³. It also helps relax muscles in the esophagus, making it easier for dogs with megaesophagus to swallow²⁴.

A study by Brown et al. (2010) showed that sildenafil helped dogs with high blood pressure in their lungs²³. Kellum and Stepien (2007) looked at 22 dogs taking sildenafil for this condition²³. Arita et al. (2013) tested imatinib, another drug, on dogs with high blood pressure in their arteries²³.

Reinero et al. (2020) made guidelines for treating high blood pressure in dogs, using studies and advice from experts²³. These guidelines show how important it is to know how sildenafil works and its role in treating dogs.

For dogs with megaesophagus, taking liquid sildenafil helped them swallow better for two weeks²⁴. But, dogs with very severe megaesophagus didn’t get much better with the drug²⁴.

Understanding how sildenafil works in dogs is key for vets. It helps them use the drug right and care for their patients better²³²⁴²⁵.

Conclusion

Sildenafil is a key medicine for dogs with heart issues like pulmonary hypertension and megaesophagus²³. It helps by making blood vessels wider, which makes the heart work less hard and boosts circulation. This leads to more energy, better exercise ability, and a happier life for dogs²⁶. Even though it’s not FDA-approved for pets, vets often use it because it’s safe and works well²⁷. Owners should talk to their vets about how to give it, its side effects, and how it might interact with other medicines.

Studies show sildenafil is great for dogs with heart problems, like pulmonary hypertension²³. It helps blood flow better and makes the heart work less hard. This means dogs can have more energy, enjoy exercise more, and feel better overall²⁶. Pet pharmacies and vets often suggest it as an off-label treatment. It’s important to work with vets to use it safely and right.

In summary, sildenafil is a big help for dogs with heart issues²⁷. By knowing how it works and how to give it, owners and vets can make dogs with heart problems feel better. This includes those with pulmonary hypertension, megaesophagus, and other heart problems.

Source Links

1. Sildenafil 20 mg Tablet (sold per tablet) | 1800PetMeds
2. How I Treat: Pulmonary Hypertension – WSAVA2013
3. Version of Viagra—Yes, That Viagra—Could Help Dogs Who Suffer From Harmful Esophagus Disorder
4. Sildenafil – Canine-Megaesophagus: All About ME
5. Sildenafil – an overview | ScienceDirect Topics
6. No title found
7. Sildenafil for Dogs: How Viagra Can Treat Megaesophagus – GoodRx
8. Sildenafil | VCA Animal Hospitals
9. Online Pharmacy
10. Vedafil (Sildenafil) – Pet Direct
11. Online Pharmacy
12. Generic version of Viagra could be the long-waited remedy for dogs with megaesophagus
13. Medication Interactions: Food, Supplements and Other Drugs
14. Isosorbide Dinitrate Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing – WebMD
15. Sildenafil for Dogs and Cats
16. Uses, Dosage & Side Effects
17. Clinical efficacy of tadalafil compared to sildenafil in treatment of moderate to severe canine pulmonary hypertension: a pilot study
18. Clinical efficacy of tadalafil compared to sildenafil in treatment of moderate to severe canine pulmonary hypertension: a pilot study
19. No title found
20. Adjunct ambrisentan therapy had clinical benefits in 5 dogs with sildenafil-refractory pulmonary hypertension
21. Viagra promising as treatment for canine eating disorder
22. Retrospective evaluation of pimobendan and sildenafil therapy for severe pulmonary hypertension due to lung disease and hypoxia in 28 dogs (2007–2013)
23. Short-term effects of sildenafil in the treatment of dogs with pulmonary hypertension secondary to degenerative mitral valve disease
24. Study shows Viagra as promising treatment for canine megaesophagus
25. Sildenafil improves heart rate variability in dogs with asymptomatic myxomatous mitral valve degeneration
26. Frontiers | Sildenafil does not have a significant effect on the portal vein velocity, cross-sectional area, and congestion index in the dog
27. Comparative single-dose pharmacokinetics of sildenafil after oral and rectal administration in healthy beagle dogs – BMC Veterinary Research